Kyle et Cody Travers sont deux frères inséparables qui survivent dans les dures rues de METROCITY. Lorsque Cody disparaît au milieu du grabuge causé par le commerce florissant de la drogue. Kyle doit reprendre les rues de ses propres mains pour le sauver.
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In Final Fight Streetwise, players assume the role of Kyle Travers. As a streetwise underground pit fighter and brother of the infamous Cody from the classic Final Fight series, Kyle must try to solve his brother's disappearance. A major element to the game is quickly building 'respect.' Earning this sought-after characteristic gives gamers a means to attain powerful new fighting skills, hardcore weapons, and a wide variety of NPC support.