Dans un futur lointain, la nanotechnologie se révolte et les nanomachines commencent à désirer le sang humain afin de créer une armée de machines meurtrières. Afin de défendre le monde d'un apocalupse certain, les joueurs contrôlent un Cyborg militaire dont l'arme de défense est une épée au plasma pouvant prendre plusieurs formes.
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From the award-winning creator of Castlevania: Lament of Innocence, comes an all new fast-paced 3D action game. In Nano Breaker's futuristic world, nano technology was originally developed to enrich humankind, but the nanomachines suddenly went awry. The machines began to harvest the blood of humans and the iron of buildings in an effort to construct an army of monster machines. In order to combat this threat, players must slash their way through hordes of enemy units to save the world from apocalypse. Featuring a main character that wields a powerful shape-shifting Plasma Blade, players assume the role of the lone hero, who must defend mankind from the deadly nanomachines.