Dans le monde futur de l'Ère Cosmique, la race humaine est divisée entre le Coordonnateurs, des êtres génétiquement améliorés, et les Naturels, des êtres non modifiés. Au cours de l'années C.E. 70 la tension entre les Coordonnateurs et les Naturels de transforme en une guerre globale.
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In the future world of the Cosmic Era, the human race is divided into genetically enhanced Coordinators and unmodified Naturals. In the year C.E. 70 the tensions between Naturals and Coordinators escalate into a global war, and Earth and space become battlefields for the robotic weapons known as mobile suits. Two young warriors, Kira Yamato of the Earth Alliance and Athrun Zala of the ZAFT forces, enter the conflict at the controls of powerful Gundam mobile suits. But there are other stories than theirs, and in this fierce conflict, many other ace pilots are creating legends of their own.