The action bridges the gap between Resident Evil 4 and Resident Evil 5, unveiling new adventures for Jill Valentine and Chris Redfield. Jill and her new partner, Parker Luciani, have been sent on board a supposedly abandoned cruise ship in the Mediterranean, to search for Chris Redfield, based on his last known GPS coordinates. Far from being empty, the ship hides danger around every corner as Jill and Parker explore the confined space of the ship and must face a menacing new horror that emerges from the darkness.