Blue Reflection takes place at Hoshinomiya Girls' High School, where players assume the role of student Hinako Shirai. When Hinako's ballet career comes to an end after a tragic accident, she closes her heart off from the rest of the world. However, her life changes when she meets her new best friends, the magical Shijou twins – Yuzu, who is adored by her classmates for her cheerful and warm personality, and Lime, who is more logical and selfish.