The U.S. Army has received a distress signal from Area 51 where a viral outbreak has just shut down the research facility. A small Hazardous Materials unit led by specialist Ethan Cole is sent to investigate. As Cole, players will delve into the mysterious confines of Area 51, discovering a deadly mutagenic side effect of the virus that controls the minds of those infected, as well as an ancient alien colony buried beneath the facility. Chilling conspiracies such as the extraterrestrial crash at Roswell and the staged lunar landing, are investigated in order to solve the enigma of Area 51 before the viral mutagen is released and irrevocably mutates all life on Earth.