In Killer 7, players take on the role of Harman Smith an unlikely assassin who leads a life as the intermediary link between seven alter egos. Switching between his seven different personalities, Harman employs each character's abilities to terminate targets he deems "deserving to die." Now a powerful underworld kingpin has unleashed violent creatures called 'Heaven's Smile.' These crazed soldiers, affixed with horrific smiles, have started to wreak havoc on city streets destroying anything unlucky enough to cross its path and overtaking the minds of the populace. It is up to the player to interchange Harman's seven 'partners' and utilize the special powers that dwell within them in order to assassinate Kun Lan, the notorious criminal overlord behind all the madness.